COVID-19. THE MOST RELEVANT PROBLEM OF OUR TIME

Keywords: COVID-19, etiology, epidemiology, clinical symptoms, complications

Abstract

Introduction. To date, detailed information on the infection of servicemen is not available in available sources. At the same time, there is information about the possible infection of a large number of soldiers, especially those who are in a confined space. The relevance of this infection for the military is that when called up for military service, when returning from business trips and vacations, these categories of persons (especially those who are in the incubation period or are asymptomatic) can bring nCoV 2019 to the unit and cause an outbreak.

The purpose of the work is to study and summarize the experience of specialists from different countries on topical issues of COVID-19.

Materials and methods. Using historical, bibliosemantic and comparative analysis and a systematic approach, the literature data on the etiological, epidemiological, clinical and diagnostic aspects of new coronavirus infection, structure and frequency of complications are summarized.

Results. The article reviews the literature on the relevance of the disease, epidemiologic issues, clinical symptoms, possible complications of COVID-19 and their incidence: pneumonia (15,7-100%), ARDS (3-90%), heart damage (myocarditis, etc.), arrhythmia, toxic hepatitis (4-53%), reactive pancreatitis, deep vein thrombosis, thromboembolism (up to 31%), coagulopathy (up to 38%), anemia (up to 15%), acute kidney damage with the development of acute renal failure (3-8%), sepsis, septic shock (4-8%), multiple organ failure, otitis, sinusitis, bronchitis, neurological complications (36.4-45.5%), acute cerebrovascular disease, stroke, cognitive impairment, ataxia, convulsions, neuralgia, skeletal muscle trauma, encephalopathy, peripheral polyneuropathy, secondary bacterial infection (6-10%), bacteremia, fungal superinfection, miscarriage (2%), intrauterine growth restriction (10%) , premature birth (39%).

Conclusions. Patients with COVID-19 can develop a variety of complications, including pneumonia, GRDS, coagulopathy, thromboembolism, liver damage. Therefore, in patients with rapid clinical deterioration, pulmonary thromboembolism should be ruled out, in addition to the development of GRDS, in the diagnosis of which CT-pulmonary angiography and additional laboratory tests to study the blood coagulation / anticoagulation system play an important role. During the epidemic period of COVID-19, when examining patients with neurological and other manifestations, physicians should consider SARS-CoV-2 infection as a differential diagnosis to avoid delayed or misdiagnosis, prevent transmission, and prevent fatalities, especially in severe cases. . The new coronavirus infection has highlighted the problems that can arise suddenly and simultaneously in many countries around the world when new infections appear, especially in cases of neglect of basic prevention measures. COVID-19 has demonstrated the enormous damage that an outbreak of infection can do to the economies of different countries in a short period of time. In view of new infections, it is necessary to radically reconsider the attitude to preventive medicine, biosafety of the country, infectious diseases and the organization of medical care for infectious diseases.

 

References

[Electronic resource]. Available from: https://www.brookings.edu/blog/order-from-chaos/2020/04/22/covid-19-and-military-readiness-preparing-for-the-long-game/

[Electronic resource]. Available from: https://www.military.com/daily-news/2020/03/16/militarys-coronavirus-cases-latest-rundown.html

[Electronic resource]. Available from: https://undark.org/2020/05/07/military-covid-19/

[Electronic resource]. Available from: https://github.com/CSSEGISandData/COVID-19)

Sean Wei Xiang Ong. Air, Surface Environmental, and Personal Protective Equipment Contamination by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) From a Symptomatic Patient / Sean Wei Xiang Ong, Yian Kim Tan, Po Ying Chia, et al. / JAMA. – 2020. – Vol.323(16). – P.1610-1612.

Neeltje van Doremalen. Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1 / Neeltje van Doremalen, Trenton Bushmaker, Dylan H. Morris et al. // N Engl J Med. – 2020. Mar 17: NEJMc2004973. [Electronic resource]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121658/

Duan S.M. Stability of SARS coronavirus in human specimens and environment and its sensitivity to heating and UV irradiation / S.M. Duan, X.S. Zhao, R.F. Wen et al. // Biomed Environ Sci. – 2003. – Vol.16(3). – P.246-55.

Kampf G. Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents / G. Kampf, D. Todt, S. Pfaender, E. Steinmann. [Electronic resource]. Available from: https://www.journalofhospitalinfection.com/article/S0195-6701(20)30046-3/fulltext

Bai Y. Presumed Asymptomatic Carrier Transmission of COVID-19 / Y. Bai, L. Yao, T. Wei et al. [Electronic resource]. Available from:https://jamanetwork.com/journals/jama/fullarticle/2762028

Nguyen H. Outbreak investigation for COVID-19 in northern Vietnam / H. Nguyen, T. Truong, N. Vana et al. [Electronic resource]. Available from: https://www.sciencedirect.com/science/article/pii/S1473309920301596

Wang J. Exploring the reasons for healthcare workers infected with novel coronavirus disease 2019 (COVID-19) in China / J. Wang, M. Zhou, F. Liu // Journal of Hospital Infection In Press, Journal Pre-proof What are Journal Pre-proof articles? [Electronic resource]. Available from: https://www.sciencedirect.com/science/article/pii/S01956701203 01018

Manal Al-Gethamy. A Case of Long-term Excretion and Subclinical Infection With Middle East Respiratory Syndrome Coronavirus in a Healthcare Worker / M. Al-Gethamy, V.M. Corman, R. Hussain et al. // Clinical Infectious Diseases. – 2015. – Vol.60 (6). – P.973–974.

Al-Tawfiq J.A. Asymptomatic Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection: Extent and implications for infection control: A systematic review / Jaffar A.Al-Tawfiq, Philippe Gautret / Travel Medicine and Infectious Disease. 2019. – Vol.27., - P.27-32.

Liu Y. Secondary attack rate and superspreading events for SARS-CoV-2 / Y. Liu, R.M. Eggo, A.J. Kucharski. (2020). [Electronic resource]. Available from: https://www.sciencedirect.com/science/article/pii/S0140673620304621

Lake M.A. What we know so far: COVID-19 current clinical knowledge and research / M.A Lake // Wellcome Trust clinical research training fellow. Clin Med (Lond). – 2020. - Vol.20(2). - P.124–127.

Adhikari S.P.. Epidemiology, causes, clinical manifestation and diagnosis, prevention and control of coronavirus disease (COVID-19) during the early outbreak period: a scoping review / S.P. Adhikari, S.Meng, Y.J. Wu et al. // Infect Dis Poverty. 2020; 9: 29. [Electronic resource]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079521/

Haider N. Passengers' destinations from China: low risk of Novel Coronavirus (2019-nCoV) transmission into Africa and South America / N.Haider, A.Yavlinsky, D.Simons et al. / Epidemiol Infect. – 2020. – Vol.148: e41. [Electronic resource]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058650/

[Electronic resource]. Available from: https://www.statista.com/statistics

[Electronic resource]. Available from: https://health-infobase.canada.ca/covid-19/epidemiological-summary-covid-19-cases.html

Guan W.J. Clinical Characteristics of Coronavirus Disease 2019 in China / W.J. Guan, Z.Y. Ni, Y. Hu et al. (2020) // N. Engl. J. Med., Feb. 28, doi:10.1056/NEJMoa2002032.

Lai C.C. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges / C.-C. Lai, T.-P. Shih, W.-C. Ko et al. // International Journal of Antimicrobial Agents. – 2020. – Vol.55, Issue 3, March 2020, 105924. March 2020, 105924. [Electronic resource]. Available from: https://www.sciencedirect.com/science/article/pii/S0924857920300674?via%3Dihub

Wu X. Co-infection with SARS-CoV-2 and Influenza A Virus in Patient with Pneumonia, China / X. Wu, Y. Cai, X.Huang et al. [Electronic resource]. Available from: https://wwwnc.cdc.gov/eid/article/26/6/20-0299_article

Nanshan Chen. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study / Nanshan Chen, Min Zhou, Xuan Dong et al. [Electronic resource]. Available from: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30211-7/fulltext].

Chen T. Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study / T. Chen, D.Wu, H.Chen et al. Electronic resource. Available from: https://www.bmj.com/content/368/bmj.m1091

Tanu S. A Review of Coronavirus Disease-2019 (COVID-19) / S.Tanu // Indian J Pediatr. – Vol.87(4). – P.281–286.

Klok F.A. Incidence of thrombotic complications in critically ill ICU patients with COVID-19 / F.A.Klok, M.J.H.A.Kruip, N.J.M.van der Meer, et al. [Electronic resource]. Available from: https://www.sciencedirect.com/science/article/pii/S0049384820301201

Huang C. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China / C. Huang, Y. Wang, X. Li et al. Electronic resource. Available from: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30183-5/fulltext

Mao L. Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China / L. Mao, H.Jin, M.Wang et al. // [Electronic resource]. Available from: https://jamanetwork.com/journals/jamaneurology/fullarticle/2764549.

Cheung KS et al. Gastrointestinal manifestations of SARS-CoV-2 infection and virus load in fecal samples from the Hong Kong cohort and systematic review and meta-analysis. Gastroenterology 2020 Apr 3; [e-pub]. (https://doi.org/10.1053/j.gastro.2020.03.065).

Published
2020-03-23
How to Cite
Trichleb , V. I., & Osyodlo , G. V. (2020). COVID-19. THE MOST RELEVANT PROBLEM OF OUR TIME. Ukrainian Journal of Military Medicine, 1(1), 5-24. https://doi.org/10.46847/ujmm.2020.1(1)-005